{"created":"2023-06-19T12:42:55.824992+00:00","id":2213,"links":{},"metadata":{"_buckets":{"deposit":"99bfdeba-fe0b-4a21-8d6e-b7881a092a72"},"_deposit":{"created_by":3,"id":"2213","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2213"},"status":"published"},"_oai":{"id":"oai:tokyo-metro-u.repo.nii.ac.jp:00002213","sets":["465:473:474:864:1165"]},"author_link":["6220","6218","6219"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-10-06","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"153","bibliographicPageStart":"1","bibliographic_titles":[{}]}]},"item_2_creator_2":{"attribute_name":"著者(ヨミ)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ヒロセ, ユウイチ"}],"nameIdentifiers":[{"nameIdentifier":"6219","nameIdentifierScheme":"WEKO"}]}]},"item_2_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"廣瀨, 雄一"}],"nameIdentifiers":[{"nameIdentifier":"6220","nameIdentifierScheme":"WEKO"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this thesis, we proposed a model for lipid bilayers, and discussed the mechanism of the\nfinite-sized domain formation together with the effects of coupling of the two monolayers.\nA lipid monolayer consisting of saturated lipid, hybrid lipid and cholesterol was considered.\nWe proposed a phenomenological Ginzburg-Landau model in which the coupling\nof the lipid composition and chain orientational vector field is considered. This coupling\narises from the liquid crystalline nature of the hybrid lipid which adjusts its orientational\norder in the tails to reduce the line tension. As a result, finite-sized domains can be\nformed. The minimization of the free energy with respect to the vector field yields an\neffective free energy which is analogous to that of 3D microemulsions (above the transition\ntemperature) and modulated structures (below the transition temperature).\nThen we considered the model for lipid bilayers comprised of two modulated monolayers\nwhich are coupled via interleaflet interactions. The structure and the dynamics of\nthe coupled modulated bilayer are investigated theoretically.\nWe first studied concentration fluctuations in bilayers occurring above the transition\ntemperature. We have calculated the static structure factors, and obtained the bilayer\nphase diagrams close to the critical temperature. In both monolayers, fluctuations are\ninduced due to the coupling, and the spectrum of the induced fluctuations is determined\nby the cross correlation of the structure factor. When the two monolayers having different\npreferred wavenumbers are coupled, the peak height at smaller wavenumber becomes larger, whereas that at a larger wavenumber remains the same. We studied the dynamics of concentration fluctuations by using the coupled time dependent Ginzburg-Landau\nequations, and calculated the intermediate structure factors of the bilayer. In general,\nconcentration fluctuations exhibit a double-exponential decay. Due to the coupling, the\ntime for the cross over of the two concentration fluctuations appears when the characteristic\nlength scale of each monolayer is different.\nThen we discussed the phase separation of the coupled modulated bilayers. Within\nthe mean field approximation, we constructed phase diagrams of the bilayer when the two\nmonolayers have the same wavenumber of the modulations. The phase behavior of the\nbilayers is described by the combinations of the stripe and the hexagonal morphologies.\nDue to the coupling effect, one of the monolayers induces micro-phase separation in the\nother monolayer. As the coupling strength increases, the asymmetric phases tend to\ndisappear. By performing numerical simulations, we obtained various phase separated\npatterns when the two monolayers have different modulations. The obtained patterns\nare approximately classified into “independent”, “intermediate” and “coincident” cases.\nThe degree of the overlap between the two monolayers is characterized by the inter-leaflet\ncorrelation of the local compositions. We showed that the initial growth rates of the most\nunstable mode are essentially identical to the decay rates of the concentration fluctuations.\nWe showed that the formation of the intermediate structures is related to the stability of\nthe concentration fluctuations occurring above the transition temperature.\nUsing the mechanism of finite-sized domain formation proposed above, we shall also\ndiscuss its relation to the biologically relevant context of lipid rafts.","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Thesis","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"首都大学東京, 2011-03-25, 博士（理学）","subitem_description_type":"Other"}]},"item_2_subject_22":{"attribute_name":"国立国会図書館分類","attribute_value_mlt":[{"subitem_subject":"UT51","subitem_subject_scheme":"NDLC"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hirose, Yuichi"}],"nameIdentifiers":[{"nameIdentifier":"6218","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-08-03"}],"displaytype":"detail","filename":"10180-001.pdf","filesize":[{"value":"20.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"10180-001.pdf","url":"https://tokyo-metro-u.repo.nii.ac.jp/record/2213/files/10180-001.pdf"},"version_id":"928e1dbe-159c-4ca0-8383-b238e4a4eda6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Concentration Fluctuations and Phase Separations in Lipid Bilayers","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Concentration Fluctuations and Phase Separations in Lipid Bilayers"}]},"item_type_id":"2","owner":"3","path":["1165"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-10-16"},"publish_date":"2013-10-16","publish_status":"0","recid":"2213","relation_version_is_last":true,"title":["Concentration Fluctuations and Phase Separations in Lipid Bilayers"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T17:12:57.824800+00:00"}